ISF Institute of Stem Cell Research
The ISF investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation. On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair.
The ISF investigates the basic molecular and cellular mechanisms for stem cell maintenance and stem cell differentiation. On this basis, the ISF develops approaches for the replacement of degenerated cell types, either by activation of endogenous stem cells or by re-programming other endogenous cells for repair.
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2024 Scientific Article in Nature Neuroscience Nat. Neurosci. 27, 1260–1273 (2024)
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.
2024 Review in Redox Biology Redox Biol. 75:103211 (2024)
Ferroptosis in health and disease.
2024 Scientific Article in Science Advances Sci. Adv. 10:eadn9998 (2024)
Multiple parallel cell lineages in the developing mammalian cerebral cortex.
2024 Scientific Article in Nature Communications Nat. Commun. 15:2866 (2024)
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.
2024 Review in Genes and Development Genes Dev. 38, 98-114 (2024)
Pan-cellular organelles and suborganelles-from common functions to cellular diversity?
2024 Scientific Article in Neuron Neuron 112, 1117-1132.e9 (2024)
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.
2024 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 300:105648 (2024)
Ribosome inactivation regulates translation elongation in neurons.
2023 Letter to the Editor in Nature medicine Nat. Med. 29, 3018-3019 (2023)
Injury-specific signals elicit plasticity in glial cells from patients with brain injury.
2023 Scientific Article in Nature medicine Nat. Med. 29, 3149–3161 (2023)
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.
2023 Scientific Article in eLife eLife 12:29 (2023)
Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.
2023 Scientific Article in Neuron Neuron 111, 1241-1263.e16 (2023)
Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.
2022 Scientific Article in Cell Reports Cell Rep. 41:111867 (2022)
Met/HGFR triggers detrimental reactive microglia in TBI.
2022 Scientific Article in Molecular Systems Biology Mol. Syst. Biol. 18:e11129 (2022)
Probing cell identity hierarchies by fate titration and collision during direct reprogramming.
2022 Scientific Article in Science Science 376:eabf9088 (2022)
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
2022 Scientific Article in Science Advances Sci. Adv. 8:eabg9287 (2022)
Excessive local host-graft connectivity in aging and amyloid-loaded brain.
2022 Scientific Article in Science Advances Sci. Adv. 8:eabg9445 (2022)
Brain injury environment critically influences the connectivity of transplanted neurons.
2022 Review in Trends in Cell Biology Trends Cell Biol. 32, 707-719 (2022)
Centrosome heterogeneity in stem cells regulates cell diversity.
2022 Scientific Article in Cells Cells 11:520 (2022)
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14797 (2022)
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
2022 Scientific Article in Advanced science Adv. Sci.:e2104979 (2022)
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Scientific Article in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 79:244 (2022)
The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone.
2022 Review in Neuron Neuron 110, 366-393 (2022)
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches.
2021Vortrag: XV European Meeting on Glial Cells in Health and Disease, 07-10 July 2021, online. (2021)
Unravelling the fate determinants of astrocytic identity and their impact in direct neuronal reprogramming.
2021 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:747667 (2021)
TUNAR lncRNA encodes a microprotein that regulates neural differentiation and neurite formation by modulating calcium dynamics.
2021 Scientific Article in Journal of Visualized Experiments J. Vis. Exp., DOI: 10.3791/63047 (2021)
Cryo-section dissection of the adult subependymal zone for accurate and deep quantitative proteome analysis.
2021 Scientific Article in EMBO Journal, The EMBO J.:e107532 (2021)
Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4.
2021 Review in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:698002 (2021)
Non-codon optimized PiggyBac transposase induces developmental brain aberrations: A call for in vivo analysis.
2021 Editorial in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 70, III-V (2021)
Editorial overview: Fluidity of cell fates - from reprogramming to repair.
2021 Scientific Article in Cell Reports Cell Rep. 36:109409 (2021)
Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
2021 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 69, 185-192 (2021)
Neuronal replacement: Concepts, achievements, and call for caution.
2021 Review in Nature Neuroscience Nat. Neurosci. 24, 312-325 (2021)
Reactive astrocyte nomenclature, definitions, and future directions.
2021 Scientific Article in Cell Cell 184, 709-722.e13 (2021)
Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
2021 Scientific Article in Cell Stem Cell Cell Stem Cell 28, 524-534.e7 (2021)
CRISPR-mediated induction of neuron-enriched mitochondrial proteins boosts direct glia-to-neuron conversion.
2021 Review in Neurobiology of Disease Neurobiol. Dis. 148:105174 (2021)
Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming.
2021 Scientific Article in Glia Glia 69, 165-181 (2021)
Repetitive injury and absence of monocytes promote astrocyte self-renewal and neurological recovery.
2020 Review in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 142, 1-66 (2020)
The regulation of cortical neurogenesis.
2020 Scientific Article in Glia Glia 69, 346-361 (2020)
Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.
2020 Review in Trends in Molecular Medicine Trends Mol. Med. 26, 890-892 (2020)
Neuronal reprogramming for brain repair: Challenges and perspectives.
2020 Scientific Article in EMBO Journal, The EMBO J.:e103373 (2020)
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 12:e11419 (2020)
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
2020 Review in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 14:32 (2020)
Filling the gaps - A call for comprehensive analysis of extracellular matrix of the glial scar in region- and injury-specific contexts.
2020 Review in Nature Nature 578, 522-524 (2020)
Turning connective tissue into neurons for 10 years.
2020 Scientific Article in Cell Stem Cell Cell Stem Cell 26, 277-293.e8 (2020)
Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis.
2019 Meeting abstract in Glia Glia 67, E689-E690 (2019)
Tlr2 and Cxcr3 pathways modulate scar formation after traumatic brain injury.
2019 Meeting abstract in Glia Glia 67, E693-E693 (2019)
Injury-induced plasticity of parenchymal astrocytes in the human cerebral cortex.
2019 Meeting abstract in Glia Glia 67, E758-E758 (2019)
Lrp1 loss in radial glia and their progeny - astrocytic dysfunctions contribute to spontaneous epileptogenesis.
2019 Scientific Article in Neuron Neuron 103, 1086-1095.e5 (2019)
Inducing different neuronal subtypes from astrocytes in the injured mouse cerebral cortex.
2019 Scientific Article in EMBO Journal, The EMBO J. 38:e100481 (2019)
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.
2019 Scientific Article in Nature Communications Nat. Commun. 10:2119 (2019)
Targeted removal of epigenetic barriers during transcriptional reprogramming.
2019 Scientific Article in Nature medicine Nat. Med. 25, 561–568 (2019)
Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia.
2019 Scientific Article in Nature Nature 567, 113-117 (2019)
The centrosome protein AKNA regulates neurogenesis via microtubule organization.
2018 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 142:e58556 (2018)
A customizable protocol for string assembly gRNA cloning (STAgR).
2018 Scientific Article in Cell Reports Cell Rep. 25, 2729-2741.e6 (2018)
A primate-specific isoform of PLEKHG6 regulates neurogenesis and neuronal migration.
2018 Scientific Article in Nature Nature 561, 253-257 (2018)
An orthogonal proteomic survey uncovers novel Zika virus host factors.
2018 Editorial in Neuron Neuron 98, 1069-1071 (2018)
Q&A Magdalena Götz
2018 Scientific Article in Nature Neuroscience Nat. Neurosci. 21, 932–940 (2018)
Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program.
2018 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 52, 65-69 (2018)
Understanding direct neuronal reprogramming - from pioneer factors to 3D chromatin.
2018 Review in Journal of Neurochemistry J. Neurochem. 146, 500-525 (2018)
Cortical progenitor biology: Key features mediating proliferation versus differentiation.
2018 Scientific Article in Cell Stem Cell Cell Stem Cell 22, 865-878.e8 (2018)
Epithelial sodium channel regulates adult neural stem cell proliferation in a flow-dependent manner.
2018 Review in Frontiers in Neuroscience Front. Neurosci. 12:5 (2018)
DNA-methylation: Master or slave of neural fate decisions?
2018 Scientific Article in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 12:57 (2018)
Mob2 insufficiency disrupts neuronal migration in the developing cortex.
2018 Review in Nature Nature 557, 329-334 (2018)
New approaches for brain repair-from rescue to reprogramming.
2018 Scientific Article in EMBO Reports EMBO Rep. 19:e45294 (2018)
Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury.
2018 Scientific Article in PLoS ONE PLoS ONE 13:e0196015 (2018)
One step generation of customizable gRNA vectors for multiplex CRISPR approaches through string assembly gRNA cloning (STAgR).
2018 Scientific Article in Glia Glia 66, 1644-1662 (2018)
Influence of white matter injury on gray matter reactive gliosis upon stab wound in the adult murine cerebral cortex.
2018 Review in Science Science 359, 639-640 (2018)
Revising concepts about adult stem cells.
2017 Editorial in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 49, IV-V (2017)
Editorial overview: Cell differentiation and development: New kids in the block - new tools and concepts opening new doors in development.
2017 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 47, 188-195 (2017)
Glial control of neurogenesis.
2017 Scientific Article in Regenerative Medicine Regen. Med. 2:29 (2017)
Neuronal replacement therapy: Previous achievements and challenges ahead.
2017 Review in Development / Company of Biologists Development 144, 2714-2718 (2017)
Programming and reprogramming the brain: A meeting of minds in neural fate.
2017 Scientific Article in Cell Stem Cell Cell Stem Cell 21, 18-34 (2017)
Direct neuronal reprogramming: Achievements, hurdles, and new roads to success.
2017 Meeting abstract in Glia Glia 65, E520-E520 (2017)
Intrinsic changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex.
2017 Meeting abstract in Glia Glia 65, E404-E405 (2017)
Differences of grey and white matter astrocytes in the intact and injured cerebral cortex.
2017 Meeting abstract in Glia Glia 65, E401-E401 (2017)
Proliferation and neural stem cell potential of diencephalic astrocytes revealed by genome-wide expression analysis is Smad4-dependent.
2017 Meeting abstract in Glia Glia 65, E121-E121 (2017)
Self-renewal and differentiation potential of reactive astrocytes in vivo.
2017 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 16, 1528-1546 (2017)
Proteome-wide identification of glycosylation-dependent interactors of Galectin-1 and Galectin-3 on mesenchymal retinal pigment epithelial cells.
2017 Scientific Article in Neurogenesis Neurogenesis 4:e1285383 (2017)
Transient CREB-mediated transcription is key in direct neuronal reprogramming.
2017 Scientific Article in Cerebral Cortex Cereb. Cortex 27, 1-16 (2017)
Changes in the proliferative program limit astrocyte Hhmeostasis in the aged post-traumatic murine cerebral cortex.
2017 Scientific Article in Neuron Neuron 93, 777-791.e3 (2017)
Time-specific effects of spindle positioning on embryonic progenitor pool composition and adult neural stem cell seeding.
2017 Scientific Article in Journal of Neuroscience J. Neurosci. 37, 4231-4242 (2017)
Respiration-deficient astrocytes survive as glycolytic cells in vivo.
2017 Scientific Article in Progress in Brain Research Prog. Brain. Res. 230, 69-97 (2017)
Brain repair from intrinsic cell sources: Turning reactive glia into neurons.
2016 Meeting abstract in Diabetologia Diabetologia 59, S259-S259 (2016)
Systemic metabolic effects exerted by a point mutation in the RED subdomain of PAX6.
2016 Other: Opinion in Cell Stem Cell Cell Stem Cell 19, 291-292 (2016)
Overcoming iPSC Obstacles.
2016 Scientific Article in Nature Nature 539, 248-253 (2016)
Transplanted embryonic neurons integrate into adult neocortical circuits.
2016 Scientific Article in Nature Nature 539, 248-253 (2016)
Transplanted embryonic neurons integrate into adult neocortical circuits.
2016 Scientific Article in BMC Genomics BMC Genomics 17:917 (2016)
CORALINA: A universal method for the generation of gRNA libraries for CRISPR-based screening.
2016 Scientific Article in Genes and Development Genes Dev. 30, 2199-2212 (2016)
Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.
2016 Scientific Article in Cell Cell 166, 867-880 (2016)
Astrocytic insulin signaling couples brain glucose uptake with nutrient availability.
2016 Review in Development / Company of Biologists Development 143, 2494-2510 (2016)
Direct neuronal reprogramming: Learning from and for development.
2016 Scientific Article in Nature Protocols Nat. Protoc. 11, 1360-1370 (2016)
Single-cell in vivo imaging of adult neural stem cells in the zebrafish telencephalon.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11812 (2016)
A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.
2016 Scientific Article in Cell Stem Cell Cell Stem Cell 18, 396-409 (2016)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal repogramming.
2016 Scientific Article in Proteomics Proteomics 16, 437-447 (2016)
In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry.
2016 Scientific Article in Developmental Biology Dev. Biol. 413, 86-103 (2016)
Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.
2015 Scientific Article in Development / Company of Biologists Development 142, 3661-3674 (2015)
Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.
2015 Scientific Article in Cold Spring Harbor Perspectives in Biology Cold Spring Harbor Perspect. Biol. 8, DOI: 10.1101/cshperspect.a018853 (2015)
Neurogenesis in the developing and adult brain - similarities and key differences.
2015 Scientific Article in Glia Glia 63, 2340-2361 (2015)
Astrocyte reactivity after brain injury - the role of galectins 1 and 3.
2015 Meeting abstract in Glia Glia 63, E297-E298 (2015)
Mitochondrial dysfunction mimics the impact of ageing on hippocampal neurogenesis.
2015 Meeting abstract in Glia Glia 63, E105-E106 (2015)
Genetic ablation of proliferating NG2-glia in the adult brain.
2015 Meeting abstract in Glia Glia 63, E64 (2015)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming.
2015 Scientific Article in Cell Stem Cell Cell Stem Cell 17, 74-88 (2015)
Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes.
2015 Editorial in Glia Glia 63, 1288-1290 (2015)
Glial stem and progenitor cells shape the brain-in ontogeny, phylogeny, and disease.
2015 Scientific Article in Science Science 348, 789-793 (2015)
Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain.
2015 Review in Glia Glia 63, 1452-1468 (2015)
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and genome-wide expression analysis.
2015 Scientific Article in Nature Neuroscience Nat. Neurosci. 18, 490-492 (2015)
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.
2015 Scientific Article in Neuron Neuron 85, 710-717 (2015)
A critical period for experience-dependent remodeling of adult-born neuron connectivity.
2015 Scientific Article in Cell and Tissue Research Cell Tissue Res. 359, 5-16 (2015)
How to make neurons-thoughts on the molecular logic of neurogenesis in the central nervous system.
2015 Scientific Article in Stem Cells Stem Cells 33, 170-182 (2015)
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells.
2014 Scientific Article in Annual Review of Cell and Developmental Biology Annu. Rev. Cell Dev. Biol. 30, 465-502 (2014)
The cell biology of neurogenesis: Toward an understanding of the development and evolution of the neocortex.
2014 Scientific Article in Stem Cell Reports Stem Cell Rep. 3, 1000-1014 (2014)
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.
2014 Scientific Article in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 8:215 (2014)
The role of α-E-catenin in cerebral cortex development: Radial glia specific effect on neuronal migration.
2014 Editorial in Developmental Cell Dev. Cell 30, 114-115 (2014)
A time and place for understanding neural stem cell specification.
2014 Review in Physiological Reviews Physiol. Rev. 94, 709-737 (2014)
Glial cells as progenitors and stem cells: New roles in the healthy and diseased brain.
2014 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 27C, 39-46 (2014)
Role of radial glial cells in cerebral cortex folding.
2014 Scientific Article in Stem Cell Reports Stem Cell Rep. 2, 153-162 (2014)
In vivo targeting of adult neural stem cells in the dentate gyrus by a split-cre approach.
2013 Scientific Article in Cell Metabolism Cell Metab. 18, 844-859 (2013)
Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance.
2013 Scientific Article in Development / Company of Biologists Development 141, 28-38 (2013)
Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb.
2013 Scientific Article in Nature Communications Nat. Commun. 4:2049 (2013)
α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1300-1308 (2013)
Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development.
2013 Scientific Article in Nature Neuroscience Nat. Neurosci. 16, 1370-1372 (2013)
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
2013 Scientific Article in Cell Stem Cell Cell Stem Cell 13, 403-418 (2013)
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.
2013 Scientific Article in Nature Communications Nat. Commun. 4:2125 (2013)
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.
2013 Scientific Article in Hippocampus Hippocampus 23, 708-719 (2013)
In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis.
2013 Scientific Article in Cell Stem Cell Cell Stem Cell 12, 426-439 (2013)
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog.
2013 Scientific Article in Cell Cell 153, 535-549 (2013)
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate.
2013 Scientific Article in Nature Neuroscience Nat. Neurosci. 16, 580-586 (2013)
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.
2013 Review in BioEssays Bioessays 35, 242-252 (2013)
Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
2013 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 110, 1152-1161 (2013)
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e54507 (2013)
Pax6 Interactions with chromatin and identification of its novel direct target genes in lens and forebrain.
2013 Scientific Article in Development / Company of Biologists Development 140, 483-486 (2013)
Radial glia - from boring cables to stem cell stars.
2013 Scientific Article in Development / Company of Biologists Development 140, 1055-1066 (2013)
The transcription factor Otx2 regulates choroid plexus development and function.
2013 Scientific Article in Glia Glia 61, 273-286 (2013)
Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men.
2013 Scientific Article in Cerebral Cortex Cereb. Cortex 23, 2552-2567 (2013)
The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.
2012 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 287, 43708-43719 (2012)
An emerging role of sonic hedgehog shedding as a modulator of heparan sulfate interactions.
2012 Scientific Article in Neurobiology of Disease Neurobiol. Dis. 48, 454-463 (2012)
Long-term genetic fate mapping of adult generated neurons in a mouse temporal lobe epilepsy model.
2012 Scientific Article in Nature Communications Nat. Commun. 3:1076 (2012)
Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle.
2012 Scientific Article in Cell Stem Cell Cell Stem Cell 11, 471-476 (2012)
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.
2012 Editorial in Nature Neuroscience Nat. Neurosci. 15, 1176-1178 (2012)
Shaping barrels: Activity moves NG2+ glia.
2012 Scientific Article in Science Science 337, 749-753 (2012)
Bergmann glial AMPA receptors are required for fine motor coordination.
2012 Scientific Article in Neuron Neuron 73, 911-924 (2012)
A radial glia-specific role of RhoA in double cortex formation.
2012 Scientific Article in Glia Glia 60, 343-357 (2012)
Stab wound injury of the zebrafish telencephalon: A model for comparative analysis of reactive gliosis.
2012 Scientific Article in Genesis : The Journal of Genetics and Development Genesis 50, 506-515 (2012)
Sox10-iCreERT2 : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.
2011 Scientific Article in Nature Protocols Nat. Protoc. 6, 1981-1989 (2011)
Prospective isolation of adult neural stem cells from the mouse subependymal zone.
2011 Scientific Article in Journal of Neuroscience J. Neurosci. 31, 12471-12482 (2011)
Genetic deletion of Cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo.
2011 Scientific Article in Nature Protocols Nat. Protoc. 6, 1847-1859 (2011)
Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level.
2011 Scientific Article in Development / Company of Biologists Development 138, 5067-5078 (2011)
The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.
2011 Scientific Article in Neural Development Neural Dev. 6:12 (2011)
Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.
2011 Scientific Article in European Journal of Neuroscience Eur. J. Neurosci. 33, 1045-1054 (2011)
Restrictions in time and space - new insights into generation of specific neuronal subtypes in the adult mammalian brain.
2011 Scientific Article in Development / Company of Biologists Development 138, 1459-1469 (2011)
Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate.
2011 Scientific Article in Brain Research Brain Res. 1376, 31-41 (2011)
EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles.
2011 Scientific Article in Glia Glia 59, 869-881 (2011)
Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury.
2011 Scientific Article in Development / Company of Biologists Development 138, 1057-1068 (2011)
Continuous live imaging of adult neural stem cell division and lineage progression in vitro.
2011 Review in Nature Reviews - Neuroscience Nat. Rev. Neurosci. 12, 88-104 (2011)
The stem cell potential of glia: Lessons from reactive gliosis.
2011 Scientific Article in Nature Protocols Nat. Protoc. 6, 214-228 (2011)
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex.
2011 Scientific Article in Cerebral Cortex Cereb. Cortex 21, 413-424 (2011)
Neuronal network formation from reprogrammed early postnatal rat cortical glial cells.
2010 Scientific Article in Cell Stem Cell Cell Stem Cell 7, 744-758 (2010)
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
2010 Scientific Article in Neuron Neuron 68, 682-694 (2010)
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.
2010 Scientific Article in Stroke Stroke 41, 2944-2999 (2010)
Modulation of fate determinants Olig2 and Pax6 in resident glia evokes spiking neuroblasts in a model of mild brain ischemia.
2010 Scientific Article in Nature Neuroscience Nat. Neurosci. 13, 1308-1309 (2010)
Making glutamatergic neurons from GABAergic progenitors.
2010 Scientific Article in Cell Stem Cell Cell Stem Cell 7, 78-89 (2010)
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
2010 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 10:39 (2010)
Relative roles of the different Pax6 domains for pancreatic alpha cell development.
2010 Scientific Article in Brain Research Reviews Brain Res. Rev. 63, 47-59 (2010)
What determines neurogenic competence in glia?
2010 Scientific Article in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 20, 400-407 (2010)
Stem cells niches during development - lessons from the cerebral cortex.
2010 Scientific Article in Journal of Cell Science J. Cell Sci. 123, 1922-1930 (2010)
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
2010 Scientific Article in Cell Stem Cell Cell Stem Cell 6, 445-456 (2010)
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging.
2010 Scientific Article in PLoS Biology PLoS Biol. 8:e1000373 (2010)
Directing astroglia from the cerebral cortex into subtype specific functional neurons.
2010 Scientific Article in Neuron Glia Biology Neuron Glia Biol. 6, 93-107 (2010)
The specific role of histone deacetylase 2 in adult neurogenesis.
2010 Scientific Article in European Journal of Neuroscience Eur. J. Neurosci. 31, 1173-1184 (2010)
PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.
2010 Scientific Article in Molecular and Cellular Biology Mol. Cell. Biol. 30, 764-780 (2010)
Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis.
2010 Scientific Article in Stem Cells Stem Cells 28, 775-787 (2010)
Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny.
2010 Scientific Article in Protoplasma Protoplasma 243, 95-103 (2010)
PAR modulation of the UV-dependent levels of flavonoid metabolites in Arabidopsis thaliana (L.) Heynh. leaf rosettes: Cumulative effects after a whole vegetative growth period.
2009 Scientific Article in Journal of Neuroscience J. Neurosci. 29, 4172-4188 (2009)
Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling.
2009 Scientific Article in Nature Neuroscience Nat. Neurosci. 12, 1524-1533 (2009)
Adult generation of glutamatergic olfactory bulb interneurons.
2009 Scientific Article in Glia Glia 57, 1630-1647 (2009)
Conditional deletion of β1-integrin in astroglia causes partial reactive gliosis.
2009 Scientific Article in Nature Neuroscience Nat. Neurosci. 12, 1229-1237 (2009)
AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
2009 Scientific Article in Cerebral Cortex Cereb. Cortex 19, (Suppl.1), i35-i143 (2009)
Late origin of glia-restricted progenitors in the developing mouse cerebral cortex.
2009 Scientific Article in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 24, 317-324 (2009)
Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures.
2008 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 105, 15570-15575 (2008)
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior.
In: Adult neurogenesis.. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008. 227-265 ( ; 52)
Similarities and differences in stem cell fate, proliferation, migration, and differentiation in distinct forebrain regions.
In: Gage, F.H.* ; Kempermann, G.* ; Song, H.* [Eds.]: Adult Neurogenesis. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008. (Cold Spring Harbor Monograph Series ; 52)
Adult neurogenesis: Similarities and differences in stem cell fate, proliferation, migration, and differentiation in distinct forebrain regions.
2008 Scientific Article in Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 38, 15-42 (2008)
Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis.
2008 Scientific Article in Journal of Neuroscience J. Neurosci. 28, 434-445 (2008)
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.
2008 Scientific Article in Cell Stem Cell Cell Stem Cell 2, 472-483 (2008)
Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion.
2008 Scientific Article in Journal of Neuroscience J. Neurosci. 28, 6439-6452 (2008)
A Dlx2- and Pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.
2008 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 105, 3581-3586 (2008)
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain.
2008 Scientific Article in Glia Glia 56, 809-820 (2008)
Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors.
2008 Scientific Article in Development / Company of Biologists Development 135, 11-28 (2008)
Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex.
2007 Scientific Article in Cell Stem Cell Cell Stem Cell 1, 529-540 (2007)
Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6.
2007 Scientific Article in Development / Company of Biologists Development 134, 2727-2738 (2007)
Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells.
2007 Scientific Article in Journal of Neuroscience J. Neurosci. 27, 11376-11388 (2007)
The marginal zone/layer i as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex.
2007 Scientific Article in Progress in Neurobiology Prog. Neurobiol. 83, 2-23 (2007)
Radial glial cell heterogeneity--the source of diverse progeny in the CNS.
2007 Scientific Article in Journal of Neuroscience J. Neurosci. 27, 8654-8664 (2007)
Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia.
2007 Scientific Article in Neural Development Neural Dev. 2:11 (2007)
Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.
2007 Scientific Article in European Journal of Neuroscience Eur. J. Neurosci. 25, 2581-2590 (2007)
Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells.
2007 Scientific Article in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 17, 338-344 (2007)
Signaling in adult neurogenesis: From stem cell niche to neuronal networks.
2007 Scientific Article in Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 34, 99-119 (2007)
Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.
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Neural stem cells: On where they hide, in which disguise, and how we may lure them out.
2006 Scientific Article in Nature Neuroscience Nat. Neurosci. 9, 470-472 (2006)
Go with the flow: Signaling from the ventricle directs neuroblasts migration.
2006 Scientific Article in Nature Neuroscience Nat. Neurosci. 9, 1099-1107 (2006)
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
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2006 Scientific Article in Development / Company of Biologists Development 133, 3245-3254 (2006)
Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes.
2006 Scientific Article in Developmental Biology Dev. Biol. 296, 239-252 (2006)
The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate.
2006 Scientific Article in Cerebral Cortex Cereb. Cortex, 1, 121-131 (2006)
P-GAP-43 is enriched in horizontal cell divisions throughout rat cortical development.
2006 Scientific Article in Developmental Biology Dev. Biol. 295, 278-293 (2006)
Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon.
2006 Scientific Article in Glia Glia 54, 21-34 (2006)
Inducible gene deletion in astroglia and radial glia-A valuable tool for functional and lineage analysis.
2005 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 102, 18183-18188 (2005)
Expression pattern of the transcription factor Olig2 in response to brain injuries: Implications for neuronal repair.
2005 Scientific Article in Neuron Neuron 46, 369-372 (2005)
Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons.
2005 Scientific Article in Nature Neuroscience Nat. Neurosci. 8, 865-872 (2005)
Neuronal fate determinants of adult olfactory bulb neurogenesis.
2005 Scientific Article in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 6, 777-788 (2005)
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2005 Scientific Article in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 69, 67-99 (2005)
The Novel Roles of Glial Cells Revisited: The Contribution of Radial Glia and Astrocytes to Neurogenesis.
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2004 Scientific Article in Journal of Comparative Neurology, The J. Comp. Neurol. 479, 168-180 (2004)
Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex.
2004 Scientific Article in Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 25, 664-678 (2004)
Regionalization and fate specification in neurospheres: The role of Olig2 and Pax6.
2004 Scientific Article in European Journal of Neuroscience Eur. J. Neurosci. 20, 2509-2523 (2004)
BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage.
2004 Scientific Article in Nature Neuroscience Nat. Neurosci. 7, 1003-1009 (2004)
Differentiation of mouse embryonic stem cells into a defined neuronal lineage.
2004 Scientific Article in Development / Company of Biologists Development 131, 6131-6140 (2004)
Molecular dissection of Pax6 function: The specific roles of the paired domain and homeodomain in brain development.
2004 Scientific Article in Plant Molecular Biology Plant Mol. Biol. 54, 817-835 (2004)
Crosstalk and differential response to abiotic and biotic stressors reflected at the transcriptional level of effector genes from secondary metabolism.
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